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In this review, we first examined the background of BDNF, then focused on its neuro-protective mechanisms against ischemic stress, and discussed the potential application of BDNF in clinic Nerve growth factor (NGF), BDNF, neurotrophins (NT) (NT-3, NT-4, NT 4/5 and NT-6) constitute the protein family of mammalian NT (2,3)

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