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According to Fennell, A.s 2020 study, Phasic Dopamine Release Magnitude Tracks Individual Differences in Sensitization of Locomotor Response following a History of Nicotine Exposure., repeated nicotine exposure significantly decreases dopamine release in the nucleus accumbens (NAc) core of the brain through changes in 62 receptor modulation

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Ingesting as little as one-third of an ounce of E-juice, which is less than the amount of liquid in a coffee creamer, may be fatal for children

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Minami J, Ishimitsu T, Matsuoka H

In the short-to-medium term (up to two years), nicotine e-cigarettes most typically caused throat or mouth irritation, headache, cough, and feeling nauseous