Ultrafine particles that can be inhaled deep into the lungs Flavoring such as diacetyl, a chemical linked to a serious lung disease Volatile organic compounds Heavy metals such as nickel, tin, and lead Cancer-causing chemicals (explained below) The process of heating the nicotine solution produces aldehyde, acetaldehyde, formaldehyde, and acrolein, which are known carcinogens
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Outcomes Primary and secondary outcomes The primary outcome was smoking cessation rate, while the secondary outcomes included the rates of the following parameters: nicotine dependency, CAT, QoL, spirometry parameters, exhaled CO, and CO binding to haemoglobin, in patients over 29 weeks after treatment in the three groups
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