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Once nicotine gets to the brain, it stimulates the release of neurotransmitters, and it is the release of dopamine, a 'reward chemical', that is responsible for the addictive effects of nicotine
Archived October 6, 2016, at the Wayback Machine RogerEbert.com
One puff isnt likely to cause major problems, but its best to avoid it altogether
In contrast, there is also a study by scientists at the University of Innsbruck which shows that epithelial cells in the mouths of smokers, e-cigarette users and snus consumers exhibit similar epigenetic changes to cancer cells