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Sensitivity test To demonstrate the stability and reliability of the meta-analysis results, a sensitivity analysis was conducted between different study subgroups according to cleft phenotype (Figure 2), the exclusion of studies with extreme results (Supplementary file Figure 6), the risk of bias (Supplementary file Figure 5) and the period of maternal ETS exposure (Supplementary file Figure 8)

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The Region has some of the highest rates in the world with overall rates of use of tobacco products other than cigarettes (including smokeless tobacco) of 14% among boys age 1315 (compared to 7% cigarette use) and 9% among girls age 1315 (compared to 2% cigarette use)

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Thats why its safe to use nicotine patches, gum or lozenges to reduce your cravings while you quit