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Glutathione Sepharose High Performance and prepacked GSTrap HP 1-ml and 5-ml columns

Data are expressed as a fold relative to parental control (no dox, no BSO), and are derived from two individual replicates performed in triplicate with SD indicated

Research Protocol Summary Study Protocol: 0.25 mg AOD-9604 administered intra-articularly via ultrasound guidance Frequency: Weekly injections Duration: 4-7 weeks in research studies Combination Therapy: 6 mg hyaluronic acid co-administered for enhanced effects Assessment Timeline: Significant improvements observed by 8-9 weeks Note: These protocols are from animal research and have not been validated for human use

Due to its very low ability to synthesize and regenerate GSH, the brain is one of the most vulnerable tissues to excess ROS 15,21

For naturally occurring B12 in food, the presence of gastric acid, pepsin, and intrinsic factor is essential for liberation and absorption

Stable-isotope tracing and metabolite extraction