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Nicotine acts as an inhibitor (or block), that attaches to cholinergic receptors (receptors for acetylcholine) in the brain that are usually used to control respiration, heart rate, memory, alertness, and muscle movement

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The previous 2 AM estimates in Spain calculated the mortality burden in never-smokers,6,7 but to do so an approximate value had to be assigned to OM in never-smokers, since these data are not available in Spain

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