Tobacco smoke contains nicotine and other chemicals, such as cadmium, that can affect central nervous system structures [69] or stimulate expression of pro-inflammatory molecules resulting in peripheral and central sensitization which can contribute to the development of headache pain [70,71,72]
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In that year, Texas teens were more frequently cigarette smokers than were the nation's teens as a whole (12.6% vs
adults used hookah, water pipes or pipes in 2017