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For retatrutide , phase 2 data published in the New England Journal of Medicine (2023) demonstrated substantial mean weight reductions over 48 weeks in adults with obesity among the highest figures reported for any pharmacological agent to date

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GIP receptor activation further enhances insulin secretion and may play a role in fat metabolism and energy storage, complementing the effects of GLP-1

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alpha-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors