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Moderate and high intensity exercise have been shown to increase GLP-1 production for both healthy individuals and those with obesity
For example, in humans our fasting normal concentration of total GLP-1 is typically 510 pmol/L and can increase up to ~40 pmol/L in response to a meal
Also, in one study, participants who took 3 grams of L-carnitine every day for 21 days had no side effects
Preclinical data suggests that GLP-1 signaling (GLP-1 receptors on myeloid lineage) may tamp down inflammasone activation and oxidative stress, which lead to DNA damage and somatic mutations