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(Source) These factors, combined with heightened regulatory scrutiny and pending legislation across multiple states, likely contributed to the 358% increase in registrations for the Vapor Technology Association and the 115% increase for JUUL

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For example, place lighters, rolling papers, or smoking accessories alongside the main product to encourage additional purchases

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The central nicotinic cholinergic receptors, namely the low affinity 7 and the high affinity 42 nicotinic receptors located in the ventral tegmental area (VTA), are stimulated by nicotine resulting in a rapid release of dopamine in the nucleus accumbens, mediating the rewarding and reinforcing effects of nicotine (25) (Figure 1)