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Gumma in the tertiary stage can mimic destructive pathologies, such as oral lymphoma or granulomatosis with polyangiitis

A separate study found similar results suggesting an increase in MUC5AC protein levels in culture human bronchial epithelial cells exposed to PG:VG aerosols [37] as well as an increase gene expression for several inflammatory markers including cytokines interleukin-6, interleukin-8 and matrix metalloproteinase-9 (MMP-9), known to play a role in the pathogenesis of COPD [37]

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