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2001 Nature Reviews/Genetics 2 : 9199 Castelao J, Yuan J, Skipper P, Tannenbaum S, Gago-Dominguez M, Crowder J, Ross R, Yu M

Over time, this can lead to chronic obstructive pulmonary disease (COPD), a progressive and debilitating lung condition

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At the endpoint, mice were sacrificed, the presence of metastatic lesions on the lungs were evaluated by ex vivo bioluminescent imaging and histological analysis