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ZER and ZER-LCNs inhibit CSE-induced NO production in RAW264.7 cells The results from NO assay suggested that RAW264.7 cells treated with 5% CSE for a duration of 24 h resulted in an approximate 3-fold increase of NO level in the cells as compared to the control (in the absence of CSE)

15 Nausea occurs in about 30% of users but can be minimised by gradually up-titrating the dose and having the tablets with food

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Additionally, nicotine has a direct impact on the gastrointestinal system, which can also lead to stomach upset, indigestion, and even vomiting

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