However, the researchers noted that the study had several limitations to be considered including that the meta-analysis was based on observational studies, that PNE had the potential to be misclassified due to most of the studies being based on self-reported data, and that there was high statistical heterogeneity across the studies
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Benowitz, who was not involved in the study, said the new findings are an important contribution to existing research but arent really ready for translation to clinical practice or regulatory standards. Benowitz, a professor at the Center for Tobacco Control and Research and Education at the University of California, San Francisco, said because the study was done on cells in a lab, it doesnt accurately assess the effect these substances have on cell and organ function in the body
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