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Multiple research studies and scientific reviews have been conducted for years to examine the relationship between nicotine and cancer risk

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The observed mtDNA gene upregulation reached significance at 5% CSE (10 weeks for MT-CYB , MT-CO2 and MT-RNR1 ), and at 6% CSE (12 weeks for MT-CYB and MT-CO2 ), but not at the early point with 3.5% CSE (4 weeks)