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For patients taking semaglutide, gastrointestinal side effects like diarrhea can make it difficult to adhere to bowel preparation guidelines

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While most cases are mild and temporary, seek medical attention if diarrhea persists beyond 4 weeks or is accompanied by severe symptoms like high fever, blood in stool, or signs of severe dehydration

Existing studies also differ substantially in population, drug type, dose, treatment duration, follow-up window, endpoint definition, and control of gastrointestinal symptoms or other state-related confounders

This combination leverages the strengths of both medications while minimizing their individual weaknesses