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There is no trace of the famous HippocraticGalenic humoral pathology, which speaks of disease as an excess (Greek plethora: sometimes a fullness or satiety) of one of the Four Humors (Blood, Phlegm, Yellow Bile, and Black Bile), but many physicians in the Roman Empire did assume a set of humors as explanation of health and disease

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Through root feeding, the nematodes may both acquire and spread the virus to new host plants