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As far as CRF1R, CRF2R, AM1R, AM2R and CLR are concerned, their ECL1 are relatively short (consisting of 811 residues) and can only form one-turn -helix to connect the adjacent transmembrane helices TM2 and TM3, contributing limited contacts with the peptides
JCI Insight 7 , 19 (2022)
Turns Fat into Energy with Jacked L-Carnitine
For CME_a, the key residues in the C1 region, N259 and E255, are crucial for its binding, further emphasizing the importance of the C1 region in mTYR (Table 4)
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