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This safety profile contrasts sharply with full growth hormone, which carries risks of diabetes development, acromegaly (abnormal tissue growth), increased cancer risk, hypertension, and other systemic effects

Research indicates that cigarette smokers, diabetics, alcohol drinkers, and individuals with digestive problems are also prone to being B12 deficient

According to Kannt & Pfenninger in Frontiers in Physiology , NAD is a critical coenzyme in mitochondrial energy metabolism, and strategies that preserve NAD have wide-ranging effects on health and performance (Kannt & Pfenninger, Frontiers in Physiology )

Joint cartilage is primarily type II collagen