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Currently, NICE guidance (NG49) emphasises lifestyle intervention as the cornerstone of NAFLD management, including weight loss of 710% of body weight, increased physical activity, and dietary modification

It also does not mean patients should alter their own medication schedule

For example, newer incretin therapies have demonstrated greater efficacy in weight reduction compared to earlier GLP-1 products during late-stage clinical trials

For Alzheimers disease and Parkinsons disease, several randomized controlled trials have been completed, yielding mixed results