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M1 microglia are capable of producing reactive oxygen species (ROS) and produce cytokines such as tumor necrosis factor- (TNF-), IL-1, IL-6, and IL-12, thereby mediating inflammatory tissue damage (115)

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Inter-Laboratory Reproducibility and Interchangeability of 3R4F and 1R6F Reference Cigarettes in Mainstream Smoke Chemical Analysis and In Vitro Toxicity Assays Abstract A new reference cigarette, 1R6F, produced by the Kentucky Tobacco Research and Development Center, has been manufactured as a substitute for the 3R4F reference cigarette because of a depletion of 3R4F stock