Front Mater 5
Investigation of potential mechanisms The influence of non-nicotine constituents on nicotine metabolism To examine the influence of non-nicotine constituents on nicotine metabolism, the blood concentrations of cotinine (the main nicotine metabolite) were determined after the injection of the drug
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TLFB reports collected during self-monitoring appeared to be an improvement over Global reports, and have some validity, but the data also suggested the limits of TLFB, and favored the validity of EMA data, both with regard to digit bias, and also as validated by objective biochemical markers of smoking
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