Two main polarisations of TAMs include M1-like macrophages, which exhibit anti-tumour activities by stimulating the adaptive immune response and inflammation and, conversely, M2-like macrophages, which exhibit tumour promoting activities by suppressing the immune response in the TME [183]
Macroeconomic enablers include the structural decline of the conventional tobacco industry, rising health literacy among 1.2 billion adult smokers, global e-commerce infrastructure enabling geographic product access, and increasing regulatory acceptance of e-cigarettes as harm-reduction tools in developed markets
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