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This typically translates to one to two cartons of cigarettes, roughly 200 to 400 cigarettes

"We proposed a novel approach that could be used to search for causal effects of health exposures, and demonstrated this approach to search for the effects of smoking heaviness," Louise Millard, lead author of the study from Bristol Medical School: Population Health Sciences, said in a statement

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Taken together, these results suggest that Parkin-dependent mitophagy and apoptosis are activated by HS, which are further exacerbated by p53 overexpression in HS-treated LO2 cells, whereas inhibition of p53 may effectively reverse this process