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Treatment with RN delivered orally at 16.9 mg/kg or intranasally at 8.44 mg/kg resulted in a significant attenuation of RGC degeneration relative to untreated controls, with both administration routes exhibiting comparable protective outcomes

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SCFAs in IBD activate GPR43/109A on epithelial cells, stabilizing HIF-1 for barrier enhancement and IL-18 production

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