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Together, the results of this study suggest that reduction of p23 expression may protect normal airway epithelial cells from some of the damaging effects of cigarette smoke

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The possible mechanisms might be the biologic and molecular pathways include enhanced insulin sensitivity, increased high-density lipoprotein (HDL) cholesterol, and improved endothelial function by decreased tissue injury via limited ischemia/reperfusion ratio induced by ethanol 35,37

They do not have the reserve to tolerate any loss of oxygen