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In addition, up-regulation of 7 nAchRs are observed in the organs of smokers, and experimentally in the pancreas and lungs of rodents following chronic exposure to nicotine or NNK (2, 95)

And while nicotine pouches may be a safer alternative to cigarettes or vaping because they dont contain the known carcinogens associated with tobacco and are not inhaled in the lungs, they still are not recommended as something people should pick up

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