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But at higher doses it can reduce testosterone, lower libido, and alter reproductive hormones

While we did not observe any high levels of acute toxicity associated with short-term CSE-EV exposure in this study, we did find that over the course of the 16-week long-term treatment period, CSE-EV-treated SV-HUC cells tended to grow increasingly slowly, ultimately exhibiting near-total growth arrest 4 weeks after the completion of the long-term colony formation assay (data not shown)

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[PubMed: 17368083] Zhu B-Q, Sun Y-P, Sudhir K, Sievers RE, Browne AE, Gao L, Hutchison SJ, Chou TM, Deedwania PC, Chatterjee K, et al