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Jan 4 2021;4(1):e2031846
Discussion Keys findings In our study, using a fully resuscitated large animal model, we demonstrated that inhibition of DPP3 with PCZ was associated with 1/ Decreased catecholamine and fluid requirements with comparable organ perfusion, as assessed by an isotopic method, 2/ Lower vascular and myocardial inflammation, 3/ Lower myocardial injury and 4/ Better pulmonary function, as reflected by higher PaO 2 /FiO 2 ratio
(2021) SEER-1 Phase 3 Trial (2023) ClinicalTrials.gov (NCT00832091) Applied Sciences (2026) He et al
No randomized controlled trials were identified
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