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25 A point of disillusionment appeared in early 1980s with the notion that Selyes concept should be replaced with humbler but more precise ideas

"Efficacy of platelet-rich plasma in the treatment of knee osteoarthritis: a meta-analysis of randomized controlled trials." Arthroscopy

83 It also had no long-term follow-up, so we dont know if the relief was lasting or if any delayed issues occurred

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One possible explanation is that low serum vitamin B12 levels would trap folate as 5-methyltetrahydrofolate, prevent the generation of methionine from homocysteine, and therefore reduce protein synthesis and lean tissue deposition

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