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Nevertheless, in the past few years, seven randomized phase III clinical trials, which tested other first-line and second-line treatments, in intermediate-stage or advanced-stage HCC patients have not found any obvious OS benefits (Llovet et al., 2015)

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Quickstart Highlights IGF-1 LR3 (Long-Arg3 Insulin-like Growth Factor-1) is a modified analog of human IGF-1 with much-reduced affinity for IGF binding proteins, giving it a substantially longer half-life and prolonged receptor activity [1] [2]