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and a JAMA Neurology randomized trial) have assessed safety and symptomatic outcomes, with some indicating a moderate, temporary benefit on GI and quality-of-life measures but varying benefits on motor scores [61]

Findings have not been validated through FDA-approved human clinical trials

The PCR product was subjected to restriction digestion with 10 U of the Bss T1I enzyme (Sibenzyme) at 60 C for 4 h followed by 2.5%-agarose gel electrophoresis

Independent replication of some findings strengthens the evidence base