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The average tumor volume in mice treated with BMS-754807 + U0126 increased about twofold during the 12-day treatment while the tumor volume increased about sevenfold in the vehicle-treated mice (Fig

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Additionally, the administration of safflower extract, which comprises both HSYA and safflower yellow (also known as carthamine yellow), elevates the mRNA levels of antioxidative enzymes and enhances the superoxide dismutase (SOD) activity in liver homogenates ( The elevation of heart function enzyme activity (troponin and CK) in the hypercholesterolemic positive control group is corroborated by histological analyses that indicated damaged cardiac tissues and oxidative stress markers ( The current findings indicated a notable reduction in vitamin D and calcium levels due to induced hypercholesterolemia in the positive control group, while treatment with safflower and atorvastatin resulted in an elevation of these levels

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