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RCTs are the gold standard for the empirical testing of a scientific hypothesis in a clinical setting 11 , and this research gap potentially raises confounding-factor and reverse-causality issues

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The impact is more severe for individuals with a history of Actiq addiction

Sensitivity analysis in observational research: introducing the E-value

In particular, the patients classified in the high-risk group identified by SPLC-RAT ( 5.6%) at initial diagnosis exhibited a higher observed 10-year SPLC incidence at 4.2%, compared to 1.4% for the low-risk group (Fig