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Inhalation of nicotine from cigarettes has been demonstrated to increase ACE2 expression in human bronchial epithelial cells via -7-subtype of the nicotine receptors (7-nAChR), with a similar increase in ACE2 expression measured in patients with COPD (Wyatt et al., 2012

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They found that smokers tended to have a larger fear response to the symbols after they had been taught to associate them with electric shocks than the non-smokers