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A recent systematic review and meta-analysis of seven clinical trials found that GLP-1R agonist treatment reduces major adverse cardiovascular events by 12% overall in type 2 diabetic patients

J Pharm Pract 23(4):367370 Mockenhaupt M, Viboud C, Dunant A, Naldi L, Halevy S, Bouwes Bavinck JN, Sidoroff A, Schneck J, Roujeau JC, Flahault A (2008) Stevens-Johnson syndrome and toxic epidermal necrolysis: assessment of medication risks with emphasis on recently marketed drugs

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Different ingredients work through different biological pathways, which directly affects their effectiveness, safety, and suitability for various skin types