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Conclusion of the aforementioned inflammatory signaling pathway cross-talk As we could learn from the previous and present research, the signal pathway crossing between hyperuricemia and periodontitis included the following 4 points (refer to Figure 3 and Figure 4 ): 1) As PAMPs, periodontal pathogens identify TLRs to stimulate the NF-B signal pathway, while MSU crystals could also activate NF-B as DAMP with the synergy of TLRs

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Notably, GABA concentrations tend to increase during early development, begin to decline between 3 and 6 months postnatally, and stabilize in adulthood

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