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We break exact linear dependency between the three explanatory variables (i.e., cohort = period age) and deal with under-identification by grouping birth cohorts into frequently used 5-year intervals, and, after confirmation of a curvilinear relationship, treat smoking as a quadratic function of age 30

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A person without nicotine addiction always has a relatively stable level of acetylcholine receptor activation

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Common immediate reactions are stinging or burning in the nostrils, watering eyes, sneezing and increased salivation

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