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416 Interestingly, Factor 1 (craving related to the relief of withdrawal and/or negative affect), which is closely related to dependence (as measured by the FTND), was the only dimension positively associated with the negative impact of tobacco on daily life, with the frequency of smoking triggered by negative emotional contexts and with the smoking history
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66 In the 2000s, as evidence of reduced lung cancer incidence and coincident increases in snus use in Sweden appeared, 67,68 manufacturers began to promote smokeless tobacco products as reduced harm alternatives
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