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Research has not shown any notable difference between nicotine derived from the tobacco leaf and synthetic nicotine as it pertains to the way the human body and brain react nor as it pertains to levels of addictiveness

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For example, genetic variants that were significantly associated with smoking initiation coded for several biologically plausible pathways, such as acetylcholine nicotinic receptors and glutamate pathways that affect reward processing and addiction

The wrapping film can be replaced according to different packaging requirements, but BOPP film is generally used