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Key Points Metabolism has a key role in the physiological turnover of synovial joint tissues, including articular cartilage In osteoarthritis (OA), chondrocytes and cells in joint tissues other than cartilage undergo metabolic alterations and shift from a resting regulatory state to a highly metabolically active state Inflammatory mediators, metabolic intermediates and immune cells influence cellular responses in the pathophysiology of OA Key metabolic pathways and mediators might be targets of future therapies for OA Abstract Metabolism is important for cartilage and synovial joint function

All GLP-1 pathway compounds carry the class boxed warning for thyroid C-cell tumor risk

Certificate CPD certificate on completion - this confirms online theory completion, not hands-on treatment competency

2018;8:a029686

Genetic Predisposition: There is a strong genetic component associated with this disease

Inter CV: 0.4-3.4