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The most common events were gastrointestinal ones and skin allergies

treated streptozotocin-induced DM rats with exenatide, a GLP-1R agonist, for 8 weeks and found that exenatide treatment attenuated the reduction in motor nerve conduction velocity and paw intraepidermal fibre density ( Himeno et al

In early or moderate cases, insulin resistance can often be improved naturally through nutrition, exercise, stress reduction, and metabolic correction

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NAD+ levels decline with age and metabolic dysfunction, and restoring them through supplementation has shown promise in animal models for improving insulin sensitivity, enhancing mitochondrial biogenesis, and promoting fat oxidation