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Cancer 91 , 12801286 (2004)

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Tell your doctor immediately if any of these unlikely but serious side effects occur: stomach pain, swelling of the hands or feet, sudden or unexplained weight gain, vision changes, hearing changes (e.g., ringing in the ears), mental/mood changes, fast/pounding heartbeat, persistent/severe headache, fainting, unusual tiredness

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In part, this is due to difficulties in establishing reliable toxicity profiles of ENDS because of variations in design, manufacturing and ingredients

People who have a history of depression or anxiety (dual diagnosis cases, when a mental illness is paired with an addiction) should be especially cautious