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Of note, the daily dosage of 1.5 mg/kg BW in mice results in a serum concentration of nicotine that is similar to the clinically relevant concentrations found in habitual cigarette smokers and nicotine-containing chewing gum users (45) and systemic inflammation (46)

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And I'll be damned if I'd defend Adam Dunn's right to chug a Bud in the dugout