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Compared with the methotrexate/leflunomide (MTX/LEF) group, MTX/HCQ-treated patients had a higher level of remission rate, accompanied by a rapid remission

However, clinical trials show that these therapies can improve pain, sensation, and nerve function, which means doctors may use them off-label when there is evidence to support their benefit

Computer-based studies such as ours have key advantages, such as reductions in costs and time, rapid analysis of large data sets, flexibility in experimental design and the ability to identify and mitigate any ethical and safety risks before conducting experiments in the laboratory, said Murcia

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Independence Blue Cross in Pennsylvania had already crossed the half-billion-dollar mark, with year-over-year increases of 45 percent suggesting the worst was still ahead

JAMA 305 , 13151321 (2011)