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The plasma level of nicotine in tobacco smokers or vapers generally averages about 2060 ng/ml depending on frequency, the number of cigarettes and/or puffs of aerosols, age, and gender (Trehy et al., 2011

Further degradation of nicotine N -oxide via ring opening rearrangement causes formation of 1-methyl 3-nicotinylpyrrodiline, 3 , and pseudooxynicotine, 4

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