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Arch Intern Med1969 Mar;123(3):261-6

But the gap between "berberine has some evidence when swallowed at 1,500 mg" and "a patch with 8.75 mg of berberine will help you lose weight through your skin" is a canyon, and the marketing fills that canyon with aspiration rather than data

44 In subsequent studies, transgenic mice expressing constitutively active MLCK (CA-MLCK), specifically within the intestinal epithelial cells, demonstrated significant gut permeability in the jejunum (using bovine serum albumin) and the colon (using creatinine and sucralose)

Elotla SF, Fouad AM, Mohamed SF, Joudeh AI, Mostafa M, Hayek SE, et al

Here is why this matters for the timeline question