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OA is now seen as a whole-joint disease in which synovitis, innate immune activation, abnormal tissue responses, and mechanical stress work together to drive joint damage and symptoms

They went on to spark relationship rumours for two years, before making their red carpet debut as a couple at the Met Gala in May 2018

That sort of massive immune response could cause an inflammatory cascade leading to organ failure, not unlike the systemic damage caused by sepsis

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