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J Biol Chem (2004) 279(22):2315865.10.1074/jbc.M314322200 202 SayinSIWahlstrmAFelinJJnttiSMarschallHUBambergKet alGut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist

It is associated with increased risk of developing non-communicable diseases including cardiovascular [2], musculoskeletal [3], diabetes [4], cancer [5], and increased risk of mortality [6]